How does RUCONEST® work?

RUCONEST® works by increasing functional C1-INH levels in the blood into the normal range. RUCONEST® also helps stop the production of kallikrein, an enzyme that activates bradykinin, which causes blood vessels to leak and certain parts of the body to swell.

For more detailed information please check EMA’s EPAR summary.

Just One Dose

achieved symptom relief with just one 50 U/kg dose** of RUCONEST® (n=43)9

** Dosing of RUCONEST® is body weight dependent and one dose is, therefore, based on patient weight as follows; <42kg = up to 1 vial, 42-84 kg = 50 U/kg (up to 2 vials), >84kg = 2 vials.

One Dose** of RUCONEST® stopped 93% of attacks for at least 3 days n=68 (259 of a total of 280 attacks)*2

Established Safety and Tolerability Profile***

One Dose** of RUCONEST® 50 U/kg raised C1-INH back to normal**** in 94% of patients3

* RUCONEST® is indicated for treatment of acute angioedema attacks in adults, adolescents, and children (aged 2 years and above) with hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency.
**Dosing of RUCONEST® is weight dependent and one dose is, therefore, based on patient weight as follows; <42kg = up to 1 vial, 42-84 kg = 50 U/kg (up to 2 vials), >84kg = 2 vials.
*** Only for adult and adolescent patients. For information on potential undesirable effects, please refer to the RUCONEST® SmPC.
**** Above the lower limit of the normal range as observed in healthy individuals (0.7-1.3 U/ml).4

Symptom Relief

WAO guidelines state that HAE patients experienced earlier relief of symptoms when treated early in the course of an attack.
A single dose of RUCONEST® worked rapidly to help patients get relief of their symptoms fast compared to placebo.

Phase II/III combined analysis of time to onset of relief

Adapted from Zuraw B, Cicardi M, Levy RJ, et al. Recombinant human C1-inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema. J Allergy Clin Immunol. 2010;126(4):821-827.