Dosing

Dosing of RUCONEST® is weight dependent and one dose is, therefore, based on patient weight as follows:

Posology in adults, adolescents and children aged 2 years and above

Body weight up to 84 kg
– One intravenous injection of 50 U/kg body weight.

Body weight of 84 kg or greater
– One intravenous injection of 4200 U (2 vials).

In the majority of cases, a single dose of RUCONEST® is sufficient to treat an acute angioedema attack. In case of an insufficient clinical response, an additional dose (50 U/kg body weight up to 4200 U) can be administered.

  • In adults and adolescents an additional dose may be administered if the patient has not responded adequately after 120 minutes.
  • In children an additional dose may be administered if the patient has not responded adequately after 60 minutes.

Not more than two doses should be administered within 24 hours.

Dosing by body weight
Body weight
RUCONEST® dose for IV injection
Volume (mL) of reconstituted solution (150 IU/mL) to be administered
<84 kg (185 lb)
50 IU per kg
Body weight in kg divided by 3
≥84 kg (185 lb)
4200 IU (2 vials)
28 mL

Administration

  • RUCONEST® is administered by slow intravenous (IV) injection over approximately 5 minutes
  • Patients may self-administer RUCONEST® after receiving appropriate training by a qualified healthcare professional
  • RUCONEST® should be administered immediately upon recognition of an HAE attack

For information on reconstitution and administration please consult the SmPC

Reconstitution and Self Administration

Instruction for the preparation and self-administration of conestat alfa (RUCONEST®)